It would have marked the actor’s first major role on American television.

The long road to bringThe Devil in the White Cityto the screen just got a little longer.

Reeves was tapped to play Burnham.

Keanu Reeves

Keanu Reeves.Steve Jennings/Getty Images

A casting announcement for Holmes has not yet been made.

Writers, actors, and directors have been trying to adapt Larson’s book for years.

DiCaprio was set to play the role of the serial killer.

Paramount reacquired the film rights in 2007.

Varietywas the first to report the news of Reeves' departure.

Representatives for Hulu and Paramount TV declined to comment.