The moment Addison (Kate Walsh) walked through the hospital doors, everything changed.Everything.
Season 5
“IT’S GEORGE.”
Those words will forever be burned into the brains ofGrey’sfans.

Credit: Karen Neal/ABC; Richard Cartwright/ABC; ABC; Scott Garfield/ABC (2); ABC; Eric McCandless/ABC; Getty Images (3)
Knight) decides to have a hero moment that results in him laying in the ER, unrecognizable.
And the moment Meredith realizes who he is?
By the end of the hour, George is gone, and Izzie’s fate is questionable as well.

ABC
When a shooter entered the hospital, he didn’t hold back.
Season 3
Cristina Yang (Sandra Oh) was free.
Meredith and Derek were “so over.”

ABC (2)
And George failed his intern exam.
Season 10
Cristina’s exit was surprisingly undramatic forGrey’s Anatomy she lived!
but the simple fact that she actually left was shocking on its own.

ABC
Season 19
Meredith declared her love for Nick (Scott Speedman)!
Jo and Link finally said those three words!
And Bailey won the Catherine Fox Award?!

ABC
And yet, despite all that, the cliffhanger of the year was that gasp!
Was the hour action-packed?
Did it pack any major twists?

ABC
Oh, and Teddy’s pregnant (with probably Owen’s baby).
Did we mention that?
That left Meredith to take Zola home on her own.

ABC
Lexie (Chyler Leigh)!
April!and major exits (DeLuca!
But by finale time, the show had used up all of its shocks.

ABC
It was a twist-free conclusion to a rollercoaster of a season.
Season 11
The season’s shocking moment came halfway through when McDreamy died (R.I.P.
), so the finale was much more focused on Meredith’s ability to finally be happy again.

ABC

ABC/John Fleenor

James Pickens Jr., Scott Speedman, Chandra Wilson, and Ellen Pompeo on ‘Grey’s Anatomy’.Raymond Liu/ABC

Ellen Pompeo and Scott Speedman on ‘Grey’s Anatomy’.Liliane Lathan/ABC

ABC

ABC

ABC

Eric McCandless/ABC

Bonnie Osborne/ABC

ABC

Meredith (Ellen Pompeo) in the OR during the season 17 finale.ABC/Richard Cartwright
